While no dengue vaccine has yet been approved for general use, several candidates are in clinical development. Data from the clinical trials can be used in mathematical models to estimate the benefits and risks and of different vaccination strategies.
A study published in PLOS NTDs suggests that even a moderately efficient dengue vaccine–if it induces long-lasting immunity–can substantially reduce disease burden. However, if immunity wanes over time, vaccination could cause years with higher numbers of sick people, unless the initial vaccination is followed by regular boosters.
Dengue disease is on the rise and presents unique challenges for prevention and control. Disease incidence (i.e., the number of new cases per year) world-wide has consistently increased for the last five decades. Efforts in the post-DDT era to control the Aedes mosquitoes that transmit the virus have failed, and the virus has spread into new regions. There are four different subtypes of the dengue virus, individuals can be infected multiple times with different viral subtypes, and re-infection is associated with an increased risk for severe disease.
Thomas Hladish, from the University of Florida in Gainesville, USA, and colleagues focused their study on Yucatán state in Mexico because dengue is a serious problem there and detailed information on disease incidence exists. The researchers started by building a mathematical model based on the primary factors that influence dengue transmission.
These include mosquito population dynamics and behavior throughout the year, human movement and demography, the build-up of immunity following natural infection in the population over time, and the immune response following re-exposure.
For full article click here
more recommended stories
Start-up Games México: A Global Entrepreneur Programme
The spokespersons of fifty independent businesses.
New medical studies uncover the inner workings of Alzheimer’s disease
WASHINGTON (EFE) .- Scientists from the.
There might be no host, yet the show must go on.
The 2019 oscars will not have.
Huachicol in Yucatan! 80,000 liters of gasoline were seized near Mérida
In a joint operation between authorities,.
Death toll in Mexico gasoline pipeline blast climbs to 94
TLAHUELIPAN HIDALGO (Reuters) – The number.
Valladolid is awaiting more tourists in the coming months
“Events like the Gastroonomic fair, the.
Real estate sector in Mexico forsees slow growth in 2019
2019 begins and several factors, including.
Don Antonio Marín quintessential Merida’s Master of Ceremonies dies at 85
On Wednesday January 16, 85-year-old professor.
Death toll reaches 85 in HIdalgo’s fuel pipeline fire
TLAHUELILPAN, Mexico (AP) — People in.
Vaqueria: a reminiscent of the “town festivities of the XVII Century