While no dengue vaccine has yet been approved for general use, several candidates are in clinical development. Data from the clinical trials can be used in mathematical models to estimate the benefits and risks and of different vaccination strategies.
A study published in PLOS NTDs suggests that even a moderately efficient dengue vaccine–if it induces long-lasting immunity–can substantially reduce disease burden. However, if immunity wanes over time, vaccination could cause years with higher numbers of sick people, unless the initial vaccination is followed by regular boosters.
Dengue disease is on the rise and presents unique challenges for prevention and control. Disease incidence (i.e., the number of new cases per year) world-wide has consistently increased for the last five decades. Efforts in the post-DDT era to control the Aedes mosquitoes that transmit the virus have failed, and the virus has spread into new regions. There are four different subtypes of the dengue virus, individuals can be infected multiple times with different viral subtypes, and re-infection is associated with an increased risk for severe disease.
Thomas Hladish, from the University of Florida in Gainesville, USA, and colleagues focused their study on Yucatán state in Mexico because dengue is a serious problem there and detailed information on disease incidence exists. The researchers started by building a mathematical model based on the primary factors that influence dengue transmission.
These include mosquito population dynamics and behavior throughout the year, human movement and demography, the build-up of immunity following natural infection in the population over time, and the immune response following re-exposure.
For full article click here
more recommended stories
Microplastics found in Yucatecan poultry
“Currently, the diet of Mexicans includes.
Bioethanol produced from the “Ramón” tree with new technique at CICY
In order to generate new fuel.
With Mexico Tourism Board closing, private sector seeks promotion options
After months of speculations, the Mexico.
Municipalities of Quintana Roo committed to save the Melipona Bee
Stephane Palmieri, president of the Maya.
Public Security agents arrest 9 Colombian armed suspects in the north of Mérida
MÉRIDA, YUC.- After intense police operations.
“Get the f— out of my country.” -Video-
Once again, racism in the United.
Mexican national dies in U.S. Border Patrol custody
(Reuters) – A 45-year-old man from.
Islas Marías… from prison to tourism – AMLO –
While some applaud the decision, others.
Progreso´s tragedy… The sad aftermath
PROGRESO YUCATAN.- Pedro Alfonso López Cabrera,.
Tycoons tell AMLO that unions are ‘extorting’ businesses
(Reuters) – A group representing some.